HomeEntertainmentNew Technology Can Repair Heart Muscles After an Attack, Say, Researchers

New Technology Can Repair Heart Muscles After an Attack, Say, Researchers

New Technology can repair the heart know the details here. In a revolutionary finding, researchers have discovered a device that can assist efficiently cure cardiac ailments in humans. After a heart attack, the method successfully regenerates and restores the heart muscles in mice. To send mutant transcription factors to the mouse heart, University of Houston researchers created a synthetic messenger ribonucleic acid (mRNA).

The proteins that regulate the transformation of DNA into RNA are known as transcription factors. The scientists used an experiment to demonstrate how two mutant transcription factors, Stein and YAP5SA, collaborate to boost the replication of heart muscle cells, or cardiomyocytes, in mice in their study, which was published in The Journal of Cardiovascular Aging.

New Technology Can Repair Heart Highlight

New Technology
  • Technology can successfully regenerate heart muscles and successfully treat human heart diseases.
  • It can also successfully treat heart attacks in mice.

According to Siyu Xiao, Ph.D. graduate, and study co-author, “what we are trying to accomplish is dedifferentiate the cardiomyocyte into a more stem cell-like condition so that they can regenerate and multiply.” Stein’s transcription changed the course of their investigation, according to another co-author Dinakar Iyer.

Cardiomyocytes develop stem-like characteristics when Stein is present, whereas YAP5SA promotes organ growth, which leads to increased cardiomyocyte replication. In a second finding, researchers found that the transcription factors healed the injured mouse heart, demonstrating the effects of Stemin and YAP5SA on the mouse heart.

They note that the myocytes multiplied at least 15 times in 24 hours after the factors were introduced.”The findings were astounding when both transcription factors were put into infarcted adult mouse hearts. According to the laboratory results, cardiac myocytes reproduced rapidly within a day, and over the course of the following month, hearts were rebuilt to nearly normal cardiac pumping performance with minimal scarring, according to lead author Robert Schwartz.

Xiao claimed that because mRNA fades within a few days, employing it in the treatment was superior to vial delivery. Additionally, there are certain biosafety issues because gene therapy cannot be readily stopped when it is given to cells using viral vectors.


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